Technical Trends: Reprogramming CAR-T Metabolism to Defeat Solid Tumors
The clinical efficacy of solid tumor CAR-T therapies hinges on overcoming metabolic barriers within the tumor microenvironment. This article explores how tracking CD8+ T cell metabolic reprogramming, glucose competitive kinetics, and cytokine secretion feedback can guide the precise engineering of persistence-enhanced cell therapies.
While Chimeric Antigen Receptor (CAR) T-cell...
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