MEA (Microelectrode Array) Measurement enables real-time, non-invasive recording of extracellular electrical signals from neuronal networks. It captures key functional parameters, including firing rate, burst activity, network synchrony, and synaptic transmission, providing a direct functional readout of neuronal health, maturation, and activity.
Microfluidic organ-on-chip/cell culture platform is a breakthrough tool in modern cell biology and biomedical research, providing scientists with a precisely controlled culture environment that allows them to simulate the growth conditions of tissues and cells in vivo, which can be used for a variety of applications, including organ chip research, drug screening and toxicity testing.
Macrophage phagocytosis is a multistep process involving particle recognition, engulfment, and intracellular degradation. It is tightly regulated by cellular activation states (M1 vs. M2), surface receptors, and the surrounding cytokine milieu. Impaired phagocytic function is associated with diseases such as chronic infections, cancer, autoimmune disorders, and neurodegenerative conditions.
As antisense oligonucleotide (ASO) platforms continue to evolve, delivery efficiency remains one of the most significant technical challenges. Emerging conjugation strategies are helping researchers overcome biological barriers and drive innovation in next-generation RNA technologies.
Antisense oligonucleotides (ASOs) have emerged as a powerful class of sequence-specific...
Gene therapy developers face persistent challenges in payload capacity, immune response, targeting, and vector production. Advanced adenoviral vector platforms provide flexible approaches for increasingly complex gene delivery applications.
As gene therapy research advances, successful vector development requires more than efficient delivery. Researchers must balance payload capacity,...
Addressing Key AAV Vector Challenges in Modern Gene Therapy
Gene therapy has entered a new era, with adeno-associated virus (AAV) vectors emerging as one of the most widely explored delivery platforms for therapeutic gene transfer. Their favorable safety profile, low immunogenicity, and ability to target different tissues make AAV vectors a valuable tool for developing treatments for...
Driven by advances in immunology, precision medicine, and complement-targeted therapies, accurate functional complement activity analysis has become increasingly important for understanding immune regulation and accelerating therapeutic development..
The complement system plays a critical role in immune regulation, inflammation, and host defense, making it an increasingly important...
Introduction of In Vivo Survival AssessmentB cell-based immunotherapy has shown great potential in cancer treatment applications. B cells in the mature tertiary lymphoid structures (TLS) could not only secrete antibodies but also mediate tumor apoptosis, phagocytosis, and antibody-dependent cellular cytotoxicity (as shown in Fig.1), which results in improving patient overall survival.
Antibody Regimens for Leukemia
Leukemia is a generic term for cancers of the bone marrow and lymphatic system. Leukemia is the most common disease in adults over 55 years old, while it is also the most often cancer in children under 15 years old. There are four main types of leukemia, each named for the rate at which the disease progresses and worsens as well as the blood cell type affected.
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